Choline Chloride Encapsulated PLGA Nanoparticles Labelled with Lanthanide Metals

Herein, choline chloride was loaded into PLGA nanoparticles to ensure its controlled release. Encapsulation efficiencies (EE) and loading capacities (LC) of them were determined. Also, the produced analyzed with Zetasizer, FT-IR, SEM, XRD. The surfaces functionalized by labeling three different natural lanthanide metals Europium, Gadolinium, Lutetium expand diagnostic therapeutic capabilities imaging tecniques. Metal confirmed SEM-EDX analysis. EE ranging between 62.5%-88.9%. LC varied from 34.9 61.4. mean size distribution obtained Zetasizer analysis free 261.0 ± 7.598 nm. Z-average encapsulated also 257.5 270 quite negative zeta potential, for example, -17.85 0.165 mV NPs showed that sufficiently stable. elemental mapping metal labeled verified procedure. By obtaining chloride-loaded labels, theranostic agents common target ability eliminate limitations detection techniques have been produced.